| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN3 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN3 |
| Gene ID: |
1182 |
| Uniprot ID: |
CLCN3_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLCN3 (NP_001230301.1). |
| Immunogen Sequence: |
MESEQLFHRGYYRNSYNSIT SASSDEELLDGAGVIMDFQT SEDDNLLDGDTAVGTHYTMT NGGSINSSTHLLDLLDEPIP GVGTYDDFHTIDWVREKCKD |
| Tissue Specificity | Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). |
| Post Translational Modifications | N-glycosylated. |
| Function | Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. |
| Protein Name | H(+/Cl(- Exchange Transporter 3Chloride Channel Protein 3Clc-3Chloride Transporter Clc-3 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: Early Endosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneCell MembraneIsoform 1 Is Localized Mainly In Late EndosomesIsoform 2: Golgi Apparatus MembraneCell ProjectionRuffle MembraneIsoform 2 Is Mainly Enriched In The GolgiColocalizes With Nherf1/Ebp50 In Membrane Ruffles |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 3 antibodyAnti-Chloride Channel Protein 3 antibodyAnti-Clc-3 antibodyAnti-Chloride Transporter Clc-3 antibodyAnti-CLCN3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
