| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLC (1-142) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLC |
| Gene ID: |
1178 |
| Uniprot ID: |
LEG10_HUMAN |
| Immunogen Region: |
1-142 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human CLC (NP_001819.2). |
| Immunogen Sequence: |
MSLLPVPYTEAASLSTGSTV TIKGRPLACFLNEPYLQVDF HTEMKEESDIVFHFQVCFGR RVVMNSREYGAWKQQVESKN MPFQDGQEFELSISVLPDKY QVMVNGQSSYTFDHRIKPEA VKMVQVWRDISLTKFNVSYL KR |
| Tissue Specificity | Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level). |
| Function | Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). |
| Protein Name | Galectin-10Gal-10Charcot-Leyden Crystal ProteinClcEosinophil LysophospholipaseLysolecithin Acylhydrolase |
| Cellular Localisation | CytoplasmCytosolCytoplasmic GranuleLocalized In Granules From Where It May Be Secreted Or Transported To Other Locations In The Cell |
| Alternative Antibody Names | Anti-Galectin-10 antibodyAnti-Gal-10 antibodyAnti-Charcot-Leyden Crystal Protein antibodyAnti-Clc antibodyAnti-Eosinophil Lysophospholipase antibodyAnti-Lysolecithin Acylhydrolase antibodyAnti-CLC antibodyAnti-LGALS10 antibodyAnti-LGALS10A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
