| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Creatine kinase B-type is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CKB |
| Gene ID: | 1152 |
| Uniprot ID: | KCRB_HUMAN |
| Specificity: | This antibody detects endogenous levels of CKB/CKM at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human CKB/CKM |
| Function | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work. |
| Protein Name | Creatine Kinase B-Type Brain Creatine Kinase B-Ck Creatine Kinase B Chain Creatine Phosphokinase B-Type Cpk-B |
| Database Links | Reactome: R-HSA-71288 Reactome: R-HSA-9696264 |
| Cellular Localisation | Cytoplasm Cytosol Mitochondrion Cell Membrane Localizes To The Mitochondria Of Thermogenic Fat Cells Via The Internal Mts-Like Signal (Imts-L) Region |
| Alternative Antibody Names | Anti-Creatine Kinase B-Type antibody Anti-Brain Creatine Kinase antibody Anti-B-Ck antibody Anti-Creatine Kinase B Chain antibody Anti-Creatine Phosphokinase B-Type antibody Anti-Cpk-B antibody Anti-CKB antibody Anti-CKBB antibody |
Information sourced from Uniprot.org