| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CIT (1000-1300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIT |
| Gene ID: |
11113 |
| Uniprot ID: |
CTRO_HUMAN |
| Immunogen Region: |
1000-1300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1300 of human CIT (NP_001193928.1). |
| Immunogen Sequence: |
EDNAELNNQNFYLSKQLDEA SGANDEIVQLRSEVDHLRRE ITEREMQLTSQKQTMEALKT TCTMLEEQVMDLEALNDELL EKERQWEAWRSVLGDEKSQF ECRVRELQRMLDTEKQSRAR ADQRITESRQVVELAVKEHK AEILALQQALKEQKLKAESL SDKLNDLEKKHAMLEMNARS LQQKLETERELKQRLLEEQA KLQQQMDLQKNHIFRLTQGL QEALDRADLLKTERSDLEY |
| Function | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. |
| Protein Name | Citron Rho-Interacting KinaseCrikSerine/Threonine-Protein Kinase 21 |
| Database Links | Reactome: R-HSA-5625900Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013149 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Citron Rho-Interacting Kinase antibodyAnti-Crik antibodyAnti-Serine/Threonine-Protein Kinase 21 antibodyAnti-CIT antibodyAnti-CRIK antibodyAnti-KIAA0949 antibodyAnti-STK21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
