| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHST6 (196-395) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHST6 |
| Gene ID: |
4166 |
| Uniprot ID: |
CHST6_HUMAN |
| Immunogen Region: |
196-395 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 196-395 of human CHST6 (NP_067628.1). |
| Immunogen Sequence: |
RIVHLVRDPRAVLRSREQTA KALARDNGIVLGTNGTWVEA DPGLRVVREVCRSHVRIAEA ATLKPPPFLRGRYRLVRFED LAREPLAEIRALYAFTGLSL TPQLEAWIHNITHGSGPGAR REAFKTSSRNALNVSQAWRH ALPFAKIRRVQELCAGALQL LGYRPVYSEDEQRNLALDLV LPRGLNGFTWASSTASHPRN |
| Tissue Specificity | Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Cooperates with B4GALT4 galactosyltransferase and B3GNT7 N-acetylglucosaminyltransferase to construct and elongate the sulfated disaccharide unit ->3Galbeta1->4(6-sulfoGlcNAcbeta)1-> within keratan sulfate polymer. Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency. Involved in sulfation of endothelial mucins such as GLYCAM1. |
| Protein Name | Carbohydrate Sulfotransferase 6Corneal N-Acetylglucosamine-6-O-SulfotransferaseC-Glcnac6stHcgn6stGalactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-BetaGst4-BetaN-Acetylglucosamine 6-O-Sulfotransferase 5Glcnac6st-5Gn6st-5 |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-3656225 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 6 antibodyAnti-Corneal N-Acetylglucosamine-6-O-Sulfotransferase antibodyAnti-C-Glcnac6st antibodyAnti-Hcgn6st antibodyAnti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Beta antibodyAnti-Gst4-Beta antibodyAnti-N-Acetylglucosamine 6-O-Sulfotransferase 5 antibodyAnti-Glcnac6st-5 antibodyAnti-Gn6st-5 antibodyAnti-CHST6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
