| Tissue Specificity | Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. |
| Protein Name | Carbohydrate Sulfotransferase 5Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-AlphaGst4-AlphaIntestinal N-Acetylglucosamine-6-O-SulfotransferaseI-Glcnac6stIntestinal Glcnac-6-SulfotransferaseHign6stN-Acetylglucosamine 6-O-Sulfotransferase 3Glcnac6st-3Gn6st-3 |
| Database Links | Reactome: R-HSA-2022854 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinGolgi MembraneEarly Secretory Pathway |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 5 antibodyAnti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Alpha antibodyAnti-Gst4-Alpha antibodyAnti-Intestinal N-Acetylglucosamine-6-O-Sulfotransferase antibodyAnti-I-Glcnac6st antibodyAnti-Intestinal Glcnac-6-Sulfotransferase antibodyAnti-Hign6st antibodyAnti-N-Acetylglucosamine 6-O-Sulfotransferase 3 antibodyAnti-Glcnac6st-3 antibodyAnti-Gn6st-3 antibodyAnti-CHST5 antibody |
Information sourced from Uniprot.org
