| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHRDL1 (289-458) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHRDL1 |
| Gene ID: |
91851 |
| Uniprot ID: |
CRDL1_HUMAN |
| Immunogen Region: |
289-458 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 289-458 of human CHRDL1 (NP_001137453.1). |
| Immunogen Sequence: |
CTCNVTKQECKKIHCPNRYP CKYPQKIDGKCCKVCPGKKA KEELPGQSFDNKGYFCGEET MPVYESVFMEDGETTRKIAL ETERPPQVEVHVWTIRKGIL QHFHIEKISKRMFEELPHFK LVTRTTLSQWKIFTEGEAQI SQMCSSRVCRTELEDLVKVL YLERSEKGHC |
| Tissue Specificity | Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. |
| Function | Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. |
| Protein Name | Chordin-Like Protein 1Neuralin-1Neurogenesin-1Ventroptin |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Chordin-Like Protein 1 antibodyAnti-Neuralin-1 antibodyAnti-Neurogenesin-1 antibodyAnti-Ventroptin antibodyAnti-CHRDL1 antibodyAnti-NRLN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
