| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHD5 (1530-1700) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHD5 |
| Gene ID: |
26038 |
| Uniprot ID: |
CHD5_HUMAN |
| Immunogen Region: |
1530-1700 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1530-1700 of human CHD5 (NP_056372.1). |
| Immunogen Sequence: |
IPEGPEGKKSGEVISSDPNT PVPASPAHLLPAPLGLPDKM EAQLGYMDEKDPGAQKPRQP LEVQALPAALDRVESEDKHE SPASKERAREERPEETEKAP PSPEQLPREEVLPEKEKILD KLELSLIHSRGDSSELRPDD TKAEEKEPIETQQNGDKEED DEGKKEDKKGK |
| Tissue Specificity | Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis. |
| Post Translational Modifications | Methylated at Gln-1390 by N6AMT1. |
| Function | Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 5Chd-5Atp-Dependent Helicase Chd5 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 5 antibodyAnti-Chd-5 antibodyAnti-Atp-Dependent Helicase Chd5 antibodyAnti-CHD5 antibodyAnti-KIAA0444 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
