| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHD1 (1501-1710) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHD1 |
| Gene ID: |
1105 |
| Uniprot ID: |
CHD1_HUMAN |
| Immunogen Region: |
1501-1710 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1501-1710 of human CHD1 (NP_001261.2). |
| Immunogen Sequence: |
IKKRQESQQNSDQNSNLNPH VIRNPDVERLKENTNHDDSS RDSYSSDRHLTQYHDHHKDR HQGDSYKKSDSRKRPYSSFS NGKDHRDWDHYKQDSRYYSD REKHRKLDDHRSRDHRSNLE GSLKDRSHSDHRSHSDHRLH SDHRSSSEYTHHKSSRDYRY HSDWQMDHRASSSGPRSPLD QRSPYGSRSPFEHSVEHKST PEHTWSSRKT |
| Tissue Specificity | Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia. |
| Function | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1Chd-1Atp-Dependent Helicase Chd1 |
| Database Links | Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusCytoplasmIs Released Into The Cytoplasm When Cells Enter Mitosis And Is Reincorporated Into Chromatin During Telophase-Cytokinesis |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1 antibodyAnti-Chd-1 antibodyAnti-Atp-Dependent Helicase Chd1 antibodyAnti-CHD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
