| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CGN |
| Gene ID: | 57530 |
| Uniprot ID: | CING_HUMAN |
| Immunogen Region: | 904-1203 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 904-1203 of human CGN (NP_065821.1). |
| Immunogen Sequence: | TSGGLSRLQDEIQRLRQALQ ASQAERDTARLDKELLAQRL QGLEQEAENKKRSQDDRARQ LKGLEEKVSRLETELDEEKN TVELLTDRVNRGRDQVDQLR TELMQERSARQDLECDKISL ERQNKDLKTRLASSEGFQKP SASLSQLESQNQLLQERLQA EEREKTVLQSTNRKLERKVK ELSIQIEDERQHVNDQKDQL SLRVKALKRQVDEAEEEIER LDGLRKKAQREVEEQHEVN |
| Tissue Specificity | Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. |
| Function | Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. |
| Protein Name | Cingulin |
| Database Links | Reactome: R-HSA-2173791 |
| Cellular Localisation | Cell JunctionTight JunctionLocalizes To The Apical Junction Complex Composed Of Tight And Adherens JunctionsColocalizes With Spef1 At Sites Of Cell-Cell Contact In Intestinal Epithelial Cells |
| Alternative Antibody Names | Anti-Cingulin antibodyAnti-CGN antibodyAnti-KIAA1319 antibody |
Information sourced from Uniprot.org