| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CENPQ (131-268) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CENPQ |
| Gene ID: |
55166 |
| Uniprot ID: |
CENPQ_HUMAN |
| Immunogen Region: |
131-268 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2). |
| Immunogen Sequence: |
MEDLTNVSSLLNMERARDKA NEEGLALLQEEIDKMVETTE LMTGNIQSLKNKIQILASEV EEEEERVKQMHQINSSGVLS LPELSQKTLKAPTLQKEILA LIPNQNALLKDLDILHNSSQ MKSMSTFIEEAYKKLDAS |
| Post Translational Modifications | Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression. |
| Function | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. |
| Protein Name | Centromere Protein QCenp-Q |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereLocalizes Exclusively In The CentromeresThe Cenpa-Cad Complex Is Probably Recruited On Centromeres By The Cenpa-Nac Complex |
| Alternative Antibody Names | Anti-Centromere Protein Q antibodyAnti-Cenp-Q antibodyAnti-CENPQ antibodyAnti-C6orf139 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
