• Western blot analysis of extracts of various cell lines, using CDKN1C/p57 Kip2 antibody (STJ23075) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CDKN1C antibody (1-107) (STJ23075)

SKU:
STJ23075

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDKN1C/p57 Kip2 (1-107) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDKN1C
Gene ID: 1028
Uniprot ID: CDN1C_HUMAN
Immunogen Region: 1-107
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human CDKN1C/p57 Kip2 (NP_000067.1).
Immunogen Sequence: MSDASLRSTSTMERLVARGT FPVLVRTSACRSLFGPVDHE ELSRELQARLAELNAEDQNR WDYDFQQDMPLRGPGRLQWT EVDSDSVPAFYRETVQVGRC RLLLAPR
Tissue Specificity Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Function Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Protein Name Cyclin-Dependent Kinase Inhibitor 1c
Cyclin-Dependent Kinase Inhibitor P57
P57kip2
Database Links Reactome: R-HSA-69231
Reactome: R-HSA-9661069
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Cyclin-Dependent Kinase Inhibitor 1c antibody
Anti-Cyclin-Dependent Kinase Inhibitor P57 antibody
Anti-P57kip2 antibody
Anti-CDKN1C antibody
Anti-KIP2 antibody

Information sourced from Uniprot.org

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