| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDH23 (40-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDH23 |
| Gene ID: |
64072 |
| Uniprot ID: |
CAD23_HUMAN |
| Immunogen Region: |
40-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-270 of human CDH23 (NP_001165402.1). |
| Immunogen Sequence: |
LLISEDTPVGSSVTQLLAQD MDNDPLVFGVSGEEASRFFA VEPDTGVVWLRQPLDRETKS EFTVEFSVSDHQGVITRKVN IQVGDVNDNAPTFHNQPYSV RIPENTPVGTPIFIVNATDP DLGAGGSVLYSFQPPSQFFA IDSARGIVTVIRELDYETTQ AYQLTVNATDQDKTRPLSTL ANLAIIITDVQDMDPIFINL PYSTNIYEHSPPGTTVRIIT AIDQDKGRPRG |
| Tissue Specificity | Particularly strong expression in the retina. Found also in the cochlea. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| Protein Name | Cadherin-23Otocadherin |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cadherin-23 antibodyAnti-Otocadherin antibodyAnti-CDH23 antibodyAnti-KIAA1774 antibodyAnti-KIAA1812 antibodyAnti-UNQ1894 antibodyAnti-PRO4340 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
