• Human lymph node stained with anti-CD45RO antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of T lymphocytes.

Anti-CD45RO antibody [UCHL1] (STJ180062)

SKU:
STJ180062

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD45RO is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: UCHL1
Conjugation: Unconjugated
Isotype: IgG2a/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:50‐100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Specificity: Positive control: Tonsil or lymph node
Immunogen: Interleukin-2-dependent human T lymphocytes
Background CD45RO (an isoform of leukocyte common antigen) is expressed on most thymocytes, monocytes, macrophages and granulocytes. It is not expressed on normal B lymphocytes. Intrathymic T cell maturation progresses from CD45RA-/CD45RO+ to CD45RA+/CD45RO-; while peripheral T cell maturation progresses from CD45RA+/CD45RO-to CD45RA-/CD45RO+. UCHL-1 reacts with mature activated T cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. Shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. It rarely stains B cell lymphomas.

Information sourced from Uniprot.org

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