Anti-CD223/LAG3 nanobody [SAA0767] (STJN000534)

Anti-CD223/LAG3 nanobody [SAA0767] (STJN000534)

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STJN000534
€473.13 - €2,040.63
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Host: Alpaca
Applications: ELISA/FC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-CD223/LAG3 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0767
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: Lag3
Gene ID: 16768
Uniprot ID: LAG3_MOUSE
Post Translational Modifications Lymphocyte activation gene 3 protein: Proteolytically cleaved by ADAM10 and ADAM17 within the connecting peptide region, leading to release of Secreted lymphocyte activation gene 3 protein (sLAG-3). ADAM10 mediates constitutive cleavage, but cleavage increases following T-cell activation, whereas shedding by ADAM17 is induced by TCR signaling in a PRKCQ-dependent manner.
Function Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II).the precise role of MHC-II-binding is however unclear. Secreted lymphocyte activation gene 3 protein: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
Protein Name Lymphocyte Activation Gene 3 Protein
Lag-3
Activation-Induced Cytidine Deaminase-Linked Autoimmunity Protein
Aida
Cd Antigen Cd223 Cleaved Into - Secreted Lymphocyte Activation Gene 3 Protein
Slag-3
Database Links Reactome: R-MMU-2132295
Cellular Localisation Lymphocyte Activation Gene 3 Protein: Cell Membrane
Single-Pass Type I Membrane Protein
Secreted Lymphocyte Activation Gene 3 Protein: Secreted
Produced Following Cleavage Of The Main Chain
Alternative Nanobody Names Anti-Lymphocyte Activation Gene 3 Protein nanobody
Anti-Lag-3 nanobody
Anti-Activation-Induced Cytidine Deaminase-Linked Autoimmunity Protein nanobody
Anti-Aida nanobody
Anti-Cd Antigen Cd223 Cleaved Into - Secreted Lymphocyte Activation Gene 3 Protein nanobody
Anti-Slag-3 nanobody
Anti-Lag3 nanobody

Information sourced from Uniprot.org

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