![Anti-CD183/CXCR3 antibody [G025H7] {FITC} (STJA0001906)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/147690/292835/STJA0001906_1__03856.1631206824.jpg?c=1 "Anti-CD183/CXCR3 antibody [G025H7] {FITC} (STJA0001906)")
![Anti-CD183/CXCR3 antibody [G025H7] {FITC} (STJA0001906)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147690/292835/STJA0001906_1__03856.1631206824.jpg?c=1 "Anti-CD183/CXCR3 antibody [G025H7] {FITC} (STJA0001906)")
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-C-X-C chemokine receptor type 3 is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | G025H7 |
| Conjugation: | FITC |
| Isotype: | IgG1k |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | CXCR3 |
| Gene ID: | 2833 |
| Uniprot ID: | CXCR3_HUMAN |
| Tissue Specificity | Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). |
| Post Translational Modifications | Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated. |
| Function | Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11. |
| Protein Name | C-X-C Chemokine Receptor Type 3 Cxc-R3 Cxcr-3 Ckr-L2 G Protein-Coupled Receptor 9 Interferon-Inducible Protein 10 Receptor Ip-10 Receptor Cd Antigen Cd183 |
| Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-418594 |
| Cellular Localisation | Isoform 1: Cell Membrane Multi-Pass Membrane Protein Isoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-C-X-C Chemokine Receptor Type 3 antibody Anti-Cxc-R3 antibody Anti-Cxcr-3 antibody Anti-Ckr-L2 antibody Anti-G Protein-Coupled Receptor 9 antibody Anti-Interferon-Inducible Protein 10 Receptor antibody Anti-Ip-10 Receptor antibody Anti-Cd Antigen Cd183 antibody Anti-CXCR3 antibody Anti-GPR9 antibody |
Information sourced from Uniprot.org