| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Low affinity immunoglobulin gamma Fc region receptor III-A and Low affinity immunoglobulin gamma Fc region receptor III-B (100-150 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCGR3AFCGR3B |
| Gene ID: |
22142215 |
| Uniprot ID: |
FCG3A_HUMANFCG3B_HUMAN |
| Immunogen Region: |
100-150 aa |
| Specificity: |
The antibody detects endogenous CD16 |
| Immunogen: |
Synthetic peptide from the human protein at the amino acid range 100-150 |
| Post Translational Modifications | Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-ACd16a AntigenFc-Gamma Riii-AlphaFc-Gamma RiiiFc-Gamma RiiiaFcriiiFcriiiaFcr-10Igg Fc Receptor Iii-2Cd Antigen Cd16a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-9664323Reactome: R-HSA-9664422 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExists Also As A Soluble Receptor |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A antibodyAnti-Cd16a Antigen antibodyAnti-Fc-Gamma Riii-Alpha antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiia antibodyAnti-Fcriii antibodyAnti-Fcriiia antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-2 antibodyAnti-Cd Antigen Cd16a antibodyAnti-FCGR3A antibodyAnti-CD16A antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
