| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CCL22 (25-93) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCL22 |
| Gene ID: |
6367 |
| Uniprot ID: |
CCL22_HUMAN |
| Immunogen Region: |
25-93 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-93 of human CCL22 (NP_002981.2). |
| Immunogen Sequence: |
GPYGANMEDSVCCRDYVRYR LPLRVVKHFYWTSDSCPRPG VVLLTFRDKEICADPRVPWV KMILNKLSQ |
| Tissue Specificity | Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. |
| Post Translational Modifications | The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes. |
| Function | May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. |
| Protein Name | C-C Motif Chemokine 22Cc Chemokine Stcp-1Mdc(1-69Macrophage-Derived ChemokineSmall-Inducible Cytokine A22Stimulated T-Cell Chemotactic Protein 1 Cleaved Into - Mdc(3-69 - Mdc(5-69 - Mdc(7-69 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 22 antibodyAnti-Cc Chemokine Stcp-1 antibodyAnti-Mdc(1-69 antibodyAnti-Macrophage-Derived Chemokine antibodyAnti-Small-Inducible Cytokine A22 antibodyAnti-Stimulated T-Cell Chemotactic Protein 1 Cleaved Into - Mdc(3-69 - Mdc(5-69 - Mdc(7-69 antibodyAnti-CCL22 antibodyAnti-MDC antibodyAnti-SCYA22 antibodyAnti-A-152E5.1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
