| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Monkey/Mouse/Pig/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CAPRIN1 (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.54 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | CAPRIN1 |
| Gene ID: | 4076 |
| Uniprot ID: | CAPR1_HUMAN |
| Immunogen Region: | 200-250 |
| Immunogen: | Synthetic peptide taken within amino acid region 200-250 on human Caprin 1 protein. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS). |
| Function | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. |
| Protein Name | Caprin-1 Cell Cycle-Associated Protein 1 Cytoplasmic Activation- And Proliferation-Associated Protein 1 Gpi-Anchored Membrane Protein 1 Gpi-Anchored Protein P137 Gpi-P137 P137gpi Membrane Component Chromosome 11 Surface Marker 1 Rna Granule Protein 105 |
| Cellular Localisation | Cytoplasm Cytoplasmic Ribonucleoprotein Granule Cytosol Cell Projection Dendrite Lamellipodium Mediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless Compartments Associated With Rna Granules At The Leading Edge Of Migrating Fibroblasts Colocalizes With Ddx3x (Microbial Infection) In Case Of Reovirus Infection Associates With The Outer Peripheries Of Viral Factories In A G3bp1 Dependent Manner |
| Alternative Antibody Names | Anti-Caprin-1 antibody Anti-Cell Cycle-Associated Protein 1 antibody Anti-Cytoplasmic Activation- And Proliferation-Associated Protein 1 antibody Anti-Gpi-Anchored Membrane Protein 1 antibody Anti-Gpi-Anchored Protein P137 antibody Anti-Gpi-P137 antibody Anti-P137gpi antibody Anti-Membrane Component Chromosome 11 Surface Marker 1 antibody Anti-Rna Granule Protein 105 antibody Anti-CAPRIN1 antibody Anti-GPIAP1 antibody Anti-GPIP137 antibody Anti-M11S1 antibody Anti-RNG105 antibody |
Information sourced from Uniprot.org