• Immunohistochemistry analysis of CACNB2 in paraffin-embedded mouse heart using CACNB2 Rabbit polyclonal antibody (STJ118477) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of CACNB2 in paraffin-embedded human colon carcinoma using CACNB2 Rabbit polyclonal antibody (STJ118477) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of CACNB2 in paraffin-embedded rat spleen using CACNB2 Rabbit polyclonal antibody (STJ118477) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of lysates from mouse heart, using CACNB2 Rabbit polyclonal antibody (STJ118477) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.

Anti-CACNB2 antibody (481-660) (STJ118477)

SKU:
STJ118477

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CACNB2 (481-660) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNB2
Gene ID: 783
Uniprot ID: CACB2_HUMAN
Immunogen Region: 481-660
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 481-660 of human CACNB2 (NP_963890.2).
Immunogen Sequence: ATSSLPLSPTLASNSQGSQG DQRTDRSAPIRSASQAEEEP SVEPVKKSQHRSSSSAPHHN HRSGTSRGLSRQETFDSETQ ESRDSAYVEPKEDYSHDHVD HYASHRDHNHRDETHGSSDH RHRESRHRSRDVDREQDHNE CNKQRSRHKSKDRYCEKDGE VISKKRNEAGEWNRDVYIRQ
Tissue Specificity Expressed in all tissues.
Post Translational Modifications Regulated through phosphorylation at Thr-554 by CaMK2D.
Function Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Beta-2
Cab2
Calcium Channel Voltage-Dependent Subunit Beta 2
Lambert-Eaton Myasthenic Syndrome Antigen B
Mysb
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-400042
Reactome: R-HSA-419037
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Reactome: R-HSA-9662360
Cellular Localisation Cell Membrane
Sarcolemma
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 antibody
Anti-Cab2 antibody
Anti-Calcium Channel Voltage-Dependent Subunit Beta 2 antibody
Anti-Lambert-Eaton Myasthenic Syndrome Antigen B antibody
Anti-Mysb antibody
Anti-CACNB2 antibody
Anti-CACNLB2 antibody
Anti-MYSB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance