| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNA2D1 (550-800) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA2D1 |
| Gene ID: |
781 |
| Uniprot ID: |
CA2D1_HUMAN |
| Immunogen Region: |
550-800 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 550-800 of human CACNA2D1 (NP_000713.2). |
| Immunogen Sequence: |
DIKVEIRNKMIDGESGEKTF RTLVKSQDERYIDKGNRTYT WTPVNGTDYSLALVLPTYSF YYIKAKLEETITQARSKKGK MKDSETLKPDNFEESGYTFI APRDYCNDLKISDNNTEFLL NFNEFIDRKTPNNPSCNADL INRVLLDAGFTNELVQNYWS KQKNIKGVKARFVVTDGGIT RVYPKEAGENWQENPETYED SFYKRSLDNDNYVFTAPYFN KSGPGAYESGIMVSKAVEI |
| Tissue Specificity | Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. |
| Post Translational Modifications | Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-1 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-1 - Voltage-Dependent Calcium Channel Subunit Delta-1 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-1 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-1 - Voltage-Dependent Calcium Channel Subunit Delta-1 antibodyAnti-CACNA2D1 antibodyAnti-CACNL2A antibodyAnti-CCHL2A antibodyAnti-MHS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
