| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CACNA1D |
| Gene ID: | 776 |
| Uniprot ID: | CAC1D_HUMAN |
| Immunogen Region: | 1882-2181 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1882-2181 of human CACNA1D (NP_000711.1). |
| Immunogen Sequence: | RQNYGYYSRYPGRNIDSERP RGYHHPQGFLEDDDSPVCYD SRRSPRRRLLPPTPASHRRS SFNFECLRRQSSQEEVPSSP IFPHRTALPLHLMQQQIMAV AGLDSSKAQKYSPSHSTRSW ATPPATPPYRDWTPCYTPLI QVEQSEALDQVNGSLPSLHR SSWYTDEPDISYRTFTPASL TVPSSFRNKNSDKQRSADSL VEAVLISEGLGRYARDPKFV SATKHEIADACDLTIDEME |
| Tissue Specificity | Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Isoform Neuronal-type: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Isoform 3: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Isoform 4: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1d Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2 Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 |
| Database Links | Reactome: R-HSA-400042 Reactome: R-HSA-419037 Reactome: R-HSA-422356 Reactome: R-HSA-9662360 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1d antibody Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2 antibody Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 antibody Anti-CACNA1D antibody Anti-CACH3 antibody Anti-CACN4 antibody Anti-CACNL1A2 antibody Anti-CCHL1A2 antibody |
Information sourced from Uniprot.org