| Tissue Specificity | Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Isoform Neuronal-type: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Isoform 3: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Isoform 4: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1dCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 |
| Database Links | Reactome: R-HSA-400042Reactome: R-HSA-419037Reactome: R-HSA-422356Reactome: R-HSA-9662360 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1d antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 antibodyAnti-CACNA1D antibodyAnti-CACH3 antibodyAnti-CACN4 antibodyAnti-CACNL1A2 antibodyAnti-CCHL1A2 antibody |
Information sourced from Uniprot.org
