| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FAAP24 |
| Gene ID: | 91442 |
| Uniprot ID: | FAP24_HUMAN |
| Immunogen Region: | 1-215 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human C19orf40 (NP_689479.1). |
| Immunogen Sequence: | MEKNPPDDTGPVHVPLGHIV ANEKWRGSQLAQEMQGKIKL IFEDGLTPDFYLSNRCCILY VTEADLVAGNGYRKRLVRVR NSNNLKGIVVVEKTRMSEQY FPALQKFTVLDLGMVLLPVA SQMEASCLVIQLVQEQTKEP SKNPLLGKKRALLLSEPSLL RTVQQIPGVGKVKAPLLLQK FPSIQQLSNASIGELEQVVG QAVAQQIHAFFTQPR |
| Function | Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. |
| Protein Name | Fanconi Anemia Core Complex-Associated Protein 24Fanconi Anemia-Associated Protein Of 24 Kda |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Fanconi Anemia Core Complex-Associated Protein 24 antibodyAnti-Fanconi Anemia-Associated Protein Of 24 Kda antibodyAnti-FAAP24 antibodyAnti-C19orf40 antibody |
Information sourced from Uniprot.org