| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-2Bmp Type-2 ReceptorBmpr-2Bone Morphogenetic Protein Receptor Type IiBmp Type Ii ReceptorBmpr-Ii |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein Receptor Type-2 antibodyAnti-Bmp Type-2 Receptor antibodyAnti-Bmpr-2 antibodyAnti-Bone Morphogenetic Protein Receptor Type Ii antibodyAnti-Bmp Type Ii Receptor antibodyAnti-Bmpr-Ii antibodyAnti-BMPR2 antibodyAnti-PPH1 antibody |
Information sourced from Uniprot.org
