Anti-BACE2 antibody (210-290 aa) (STJ192506)

SKU:
STJ192506

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Beta-secretase 2 (210-290 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BACE2
Gene ID: 25825
Uniprot ID: BACE2_HUMAN
Immunogen Region: 210-290 aa
Specificity: BACE2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 210-290
Post Translational Modifications Undergoes autoproteolytic cleavage. Glycosylated.
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Protein Name Beta-Secretase 2
Aspartic-Like Protease 56 Kda
Aspartyl Protease 1
Asp1
Asp 1
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2
Beta-Site App Cleaving Enzyme 2
Down Region Aspartic Protease
Drap
Memapsin-1
Membrane-Associated Aspartic Protease 1
Theta-Secretase
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Endoplasmic Reticulum
Endosome
Melanosome
Colocalizes With Pmel In Stage I And Ii Melanosomes
Alternative Antibody Names Anti-Beta-Secretase 2 antibody
Anti-Aspartic-Like Protease 56 Kda antibody
Anti-Aspartyl Protease 1 antibody
Anti-Asp1 antibody
Anti-Asp 1 antibody
Anti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibody
Anti-Beta-Site App Cleaving Enzyme 2 antibody
Anti-Down Region Aspartic Protease antibody
Anti-Drap antibody
Anti-Memapsin-1 antibody
Anti-Membrane-Associated Aspartic Protease 1 antibody
Anti-Theta-Secretase antibody
Anti-BACE2 antibody
Anti-AEPLC antibody
Anti-ALP56 antibody
Anti-ASP21 antibody
Anti-CDA13 antibody
Anti-UNQ418 antibody
Anti-PRO852 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance