| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AZIN2 |
| Gene ID: | 113451 |
| Uniprot ID: | AZIN2_HUMAN |
| Immunogen Region: | 1-360 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human AZIN2 (NP_443724.1). |
| Immunogen Sequence: | MAGYLSESDFVMVEEGFSTR DLLKELTLGASQATTDEVAA FFVADLGAIVRKHFCFLKCL PRVRPFYAVKCNSSPGVLKV LAQLGLGFSCANKAEMELVQ HIGIPASKIICANPCKQIAQ IKYAAKHGIQLLSFDNEMEL AKVVKSHPSAKMVLCIATDD SHSLSCLSLKFGVSLKSCRH LLENAKKHHVEVVGVSFHIG SGCPDPQAYAQSIADARLVF EMGTELGHKMHVLDLGGGF |
| Tissue Specificity | Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. |
| Post Translational Modifications | Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner. |
| Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking. |
| Protein Name | Antizyme Inhibitor 2 Azi2 Arginine Decarboxylase Adc Argdc Ornithine Decarboxylase-Like Protein Odc-Like Protein Ornithine Decarboxylase Paralog Odc-P |
| Database Links | Reactome: R-HSA-351143 |
| Cellular Localisation | Nucleus Cytoplasm Perinuclear Region Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytoplasmic Granule Cell Projection Axon Dendrite Perikaryon Colocalizes With Kdel Receptors In Er-Golgi Intermediate Compartment (Ergic) Translocates From The Ergic Structure To The Cytoplasm In An Antizyme-Dependent Manner Localizes With Vesicle-Associated Membrane Protein Vamp8 In The Vicinity Of The Plasma Membrane Within Serotonin-Containing Secretory Granules Detected As Vesicle-Like Pattern In Neurite Outgrowths Localizes To The Vesicular Compartments Of The Secretory Pathway Predominantly In The Trans-Golgi Network (Tgn) |
| Alternative Antibody Names | Anti-Antizyme Inhibitor 2 antibody Anti-Azi2 antibody Anti-Arginine Decarboxylase antibody Anti-Adc antibody Anti-Argdc antibody Anti-Ornithine Decarboxylase-Like Protein antibody Anti-Odc-Like Protein antibody Anti-Ornithine Decarboxylase Paralog antibody Anti-Odc-P antibody Anti-AZIN2 antibody Anti-ADC antibody Anti-KIAA1945 antibody Anti-ODCP antibody |
Information sourced from Uniprot.org