| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AZIN2 (1-360) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AZIN2 |
| Gene ID: |
113451 |
| Uniprot ID: |
AZIN2_HUMAN |
| Immunogen Region: |
1-360 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human AZIN2 (NP_443724.1). |
| Immunogen Sequence: |
MAGYLSESDFVMVEEGFSTR DLLKELTLGASQATTDEVAA FFVADLGAIVRKHFCFLKCL PRVRPFYAVKCNSSPGVLKV LAQLGLGFSCANKAEMELVQ HIGIPASKIICANPCKQIAQ IKYAAKHGIQLLSFDNEMEL AKVVKSHPSAKMVLCIATDD SHSLSCLSLKFGVSLKSCRH LLENAKKHHVEVVGVSFHIG SGCPDPQAYAQSIADARLVF EMGTELGHKMHVLDLGGGF |
| Tissue Specificity | Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. |
| Post Translational Modifications | Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner. |
| Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking. |
| Protein Name | Antizyme Inhibitor 2Azi2Arginine DecarboxylaseAdcArgdcOrnithine Decarboxylase-Like ProteinOdc-Like ProteinOrnithine Decarboxylase ParalogOdc-P |
| Database Links | Reactome: R-HSA-351143 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionMembraneCytoplasmic VesicleEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkTrans-Golgi NetworkCytoplasmic GranuleCell ProjectionAxonDendritePerikaryonColocalizes With Kdel Receptors In Er-Golgi Intermediate Compartment (Ergic)Translocates From The Ergic Structure To The Cytoplasm In An Antizyme-Dependent MannerLocalizes With Vesicle-Associated Membrane Protein Vamp8 In The Vicinity Of The Plasma Membrane Within Serotonin-Containing Secretory GranulesDetected As Vesicle-Like Pattern In Neurite OutgrowthsLocalizes To The Vesicular Compartments Of The Secretory PathwayPredominantly In The Trans-Golgi Network (Tgn) |
| Alternative Antibody Names | Anti-Antizyme Inhibitor 2 antibodyAnti-Azi2 antibodyAnti-Arginine Decarboxylase antibodyAnti-Adc antibodyAnti-Argdc antibodyAnti-Ornithine Decarboxylase-Like Protein antibodyAnti-Odc-Like Protein antibodyAnti-Ornithine Decarboxylase Paralog antibodyAnti-Odc-P antibodyAnti-AZIN2 antibodyAnti-ADC antibodyAnti-KIAA1945 antibodyAnti-ODCP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
