| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:10000-1:30000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATP5F1B |
| Gene ID: | 506 |
| Uniprot ID: | ATPB_HUMAN |
| Immunogen Region: | 230-529 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-529 of human ATPB (NP_001677.2). |
| Immunogen Sequence: | YSVFAGVGERTREGNDLYHE MIESGVINLKDATSKVALVY GQMNEPPGARARVALTGLTV AEYFRDQEGQDVLLFIDNIF RFTQAGSEVSALLGRIPSAV GYQPTLATDMGTMQERITTT KKGSITSVQAIYVPADDLTD PAPATTFAHLDATTVLSRAI AELGIYPAVDPLDSTSRIMD PNIVGSEHYDVARGVQKILQ DYKSLQDIIAILGMDELSEE DKLTVSRARKIQRFLSQPF |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. |
| Protein Name | Atp Synthase Subunit Beta - Mitochondrial Atp Synthase F1 Subunit Beta |
| Database Links | Reactome: R-HSA-1268020 Reactome: R-HSA-163210 Reactome: R-HSA-2151201 Reactome: R-HSA-8949613 Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner Membrane Peripheral Membrane Protein Matrix Side |
| Alternative Antibody Names | Anti-Atp Synthase Subunit Beta - Mitochondrial antibody Anti-Atp Synthase F1 Subunit Beta antibody Anti-ATP5F1B antibody Anti-ATP5B antibody Anti-ATPMB antibody Anti-ATPSB antibody |
Information sourced from Uniprot.org