| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASCC2 (488-757) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASCC2 |
| Gene ID: |
84164 |
| Uniprot ID: |
ASCC2_HUMAN |
| Immunogen Region: |
488-757 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 488-757 of human ASCC2 (NP_115580.2). |
| Immunogen Sequence: |
LACLEYYHYDPEQVINNILE ERLAPTLSQLDRNLDREMKP DPTPLLTSRHNVFQNDEFDV FSRDSVDLSRVHKGKSTRKE ENTRSLLNDKRAVAAQRQRY EQYSVVVEEVPLQPGESLPY HSVYYEDEYDDTYDGNQVGA NDADSDDELISRRPFTIPQV LRTKVPREGQEEDDDDEEDD ADEEAPKPDHFVQDPAVLRE KAEARRMAFLAKKGYRHDSS TAVAGSPRGHGQSRETTQE |
| Tissue Specificity | Ubiquitous. |
| Function | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes. |
| Protein Name | Activating Signal Cointegrator 1 Complex Subunit 2Asc-1 Complex Subunit P100Trip4 Complex Subunit P100 |
| Database Links | Reactome: R-HSA-112126 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With The Spliceosomal Components Prpf8 And Snrnp200/Brr2 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna DamageColocalizes With Rnf113a And 'Lys-63'-Linked Polyubiquitinated ProteinsAlkbh3 And Ascc3 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 2 antibodyAnti-Asc-1 Complex Subunit P100 antibodyAnti-Trip4 Complex Subunit P100 antibodyAnti-ASCC2 antibodyAnti-ASC1P100 antibodyAnti-RQT3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
