| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARSB (404-533) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARSB |
| Gene ID: |
411 |
| Uniprot ID: |
ARSB_HUMAN |
| Immunogen Region: |
404-533 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 404-533 of human ARSB (NP_000037.2). |
| Immunogen Sequence: |
PCPRNSMAPAKDDSSLPEYS AFNTSVHAAIRHGNWKLLTG YPGCGYWFPPPSQYNVSEIP SSDPPTKTLWLFDIDRDPEE RHDLSREYPHIVTKLLSRLQ FYHKHSVPVYFPAQDPRCDP KATGVWGPWM |
| Post Translational Modifications | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD). |
| Function | Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. |
| Protein Name | Arylsulfatase BAsbN-Acetylgalactosamine-4-SulfataseG4s |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-1663150Reactome: R-HSA-2024101Reactome: R-HSA-2206285Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeCell Surface |
| Alternative Antibody Names | Anti-Arylsulfatase B antibodyAnti-Asb antibodyAnti-N-Acetylgalactosamine-4-Sulfatase antibodyAnti-G4s antibodyAnti-ARSB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
