| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARAP1 (834-1133) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARAP1 |
| Gene ID: |
116985 |
| Uniprot ID: |
ARAP1_HUMAN |
| Immunogen Region: |
834-1133 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 834-1133 of human ARAP1 (NP_001128662.1). |
| Immunogen Sequence: |
SVDEEELRKQREEITAIVKM RVAGTASGTQHAGDFICTVY LEEKKAETEQHIKVPASMTA EELTLEILDRRNVGIREKDY WTCFEVNEREEAERPLHFAE KVLPILHGLGTDSHLVVKKH QAMEAMLLYLASRVGDTKHG MMKFREDRSLLGLGLPSGGF HDRYFILNSSCLRLYKEVRS HRPEKEWPIKSLKVYLGVKK KLRPPTCWGFTVVHETEKHE KQQWYLCCDTQMELREWFA |
| Tissue Specificity | Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5. |
| Protein Name | Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 1Centaurin-Delta-2Cnt-D2 |
| Database Links | Reactome: R-HSA-8849469Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmGolgi ApparatusGolgi Stack MembranePeripheral Membrane ProteinCell MembraneAssociated With Golgi Stacks In Resting CellsThroughout The Cytoplasm And In Surface Protrusion In Cells That Are In The Process Of Attaching To A Surface And Spreading |
| Alternative Antibody Names | Anti-Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 1 antibodyAnti-Centaurin-Delta-2 antibodyAnti-Cnt-D2 antibodyAnti-ARAP1 antibodyAnti-CENTD2 antibodyAnti-KIAA0782 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
