| Tissue Specificity | Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. |
| Function | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. |
| Protein Name | Anoctamin-6Small-Conductance Calcium-Activated Nonselective Cation ChannelScan ChannelTransmembrane Protein 16f |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-6798695Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinShows An Intracellular Localization |
| Alternative Antibody Names | Anti-Anoctamin-6 antibodyAnti-Small-Conductance Calcium-Activated Nonselective Cation Channel antibodyAnti-Scan Channel antibodyAnti-Transmembrane Protein 16f antibodyAnti-ANO6 antibodyAnti-TMEM16F antibody |
Information sourced from Uniprot.org
