| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCC3 (830-950) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCC3 |
| Gene ID: |
8714 |
| Uniprot ID: |
MRP3_HUMAN |
| Immunogen Region: |
830-950 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 830-950 of human ABCC3 (NP_003777.2). |
| Immunogen Sequence: |
SEMGPYPALLQRNGSFANFL CNYAPDEDQGHLEDSWTALE GAEDKEALLIEDTLSNHTDL TDNDPVTYVVQKQFMRQLSA LSSDGEGQGRPVPRRHLGPS EKVQVTEAKADGALTQEEKA A |
| Tissue Specificity | Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 3 Canalicular Multispecific Organic Anion Transporter 2Multi-Specific Organic Anion Transporter DMoat-DMultidrug Resistance-Associated Protein 3 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-382556Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneLocalized To The Basolateral Membrane Of EnterocytesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 3 antibodyAnti-Canalicular Multispecific Organic Anion Transporter 2 antibodyAnti-Multi-Specific Organic Anion Transporter D antibodyAnti-Moat-D antibodyAnti-Multidrug Resistance-Associated Protein 3 antibodyAnti-ABCC3 antibodyAnti-CMOAT2 antibodyAnti-MLP2 antibodyAnti-MRP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
