| Tissue Specificity | Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level). |
| Post Translational Modifications | Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation. |
| Function | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. |
| Protein Name | Ankyrin Repeat Domain-Containing Protein 2Skeletal Muscle Ankyrin Repeat ProteinHarpp |
| Cellular Localisation | CytoplasmMyofibrilSarcomereI BandCytosolNucleusPml BodyIn The Sarcoplasm Of Differentiated Striated Muscle CellsWhere It Is Cytosolic And Enriched In The I BandIn Nucleus And Pml Bodies Of Proliferating And Undifferentiated MyoblastsAssociates With The Euchromatin In The Nucleus Of Myocytes Upon Muscle Stress |
| Alternative Antibody Names | Anti-Ankyrin Repeat Domain-Containing Protein 2 antibodyAnti-Skeletal Muscle Ankyrin Repeat Protein antibodyAnti-Harpp antibodyAnti-ANKRD2 antibodyAnti-ARPP antibody |
Information sourced from Uniprot.org
