| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ANG (25-147) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANG |
| Gene ID: |
283 |
| Uniprot ID: |
ANGI_HUMAN |
| Immunogen Region: |
25-147 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of human ANG (NP_001136.1). |
| Immunogen Sequence: |
QDNSRYTHFLTQHYDAKPQG RDDRYCESIMRRRGLTSPCK DINTFIHGNKRSIKAICENK NGNPHRENLRISKSSFQVTT CKLHGGSPWPPCQYRATAGF RNVVVACENGLPVHLDQSIF RRP |
| Tissue Specificity | Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. |
| Function | Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells.once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. |
| Protein Name | AngiogeninRibonuclease 5Rnase 5 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-9708296 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle LumenSecretedNucleusNucleolusRapidly Endocytosed By Target Cells And Translocated To The Nucleus Where It Accumulates In The Nucleolus And Binds To Dna |
| Alternative Antibody Names | Anti-Angiogenin antibodyAnti-Ribonuclease 5 antibodyAnti-Rnase 5 antibodyAnti-ANG antibodyAnti-RNASE5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
