| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-AMER1 (550-660) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S7MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AMER1 |
| Gene ID: |
139285 |
| Uniprot ID: |
AMER1_HUMAN |
| Immunogen Region: |
550-660 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 550-660 of human AMER1 (NP_689637.3). |
| Immunogen Sequence: |
PPGAMETEEERLVTIQKQLL YWELRREQLEAQEARAREAH AREAHAREAYTREAYGREAY AREAHTWEAHGREARTREAQ AREVRCRETQVRETQARQEK PVLEYQMRPLG |
| Tissue Specificity | Detected in fetal and adult kidney, brain and spleen. |
| Function | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. |
| Protein Name | Apc Membrane Recruitment Protein 1Amer1Protein Fam123bWilms Tumor Gene On The X Chromosome Protein |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusShuttles Between Nucleus And CytoplasmDetected In Nuclear Paraspeckles That Are Found Close To Splicing SpecklesTranslocates To The Cell Membrane Following Binding To Ptdins(45)P2 |
| Alternative Antibody Names | Anti-Apc Membrane Recruitment Protein 1 antibodyAnti-Amer1 antibodyAnti-Protein Fam123b antibodyAnti-Wilms Tumor Gene On The X Chromosome Protein antibodyAnti-AMER1 antibodyAnti-FAM123B antibodyAnti-WTX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
