| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AJUBA (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AJUBA |
| Gene ID: |
84962 |
| Uniprot ID: |
AJUBA_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Ajuba (NP_116265.1). |
| Immunogen Sequence: |
MERLGEKASRLLEKFGRRKG ESSRSGSDGTPGPGKGRLSG LGGPRKSGPRGATGGPGDEP LEPAREQGSLDAERNQRGSF EAPRYEGSFPAGPPPTRALP |
| Post Translational Modifications | Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA. |
| Function | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. |
| Protein Name | Lim Domain-Containing Protein Ajuba |
| Database Links | Reactome: R-HSA-1234176Reactome: R-HSA-2565942Reactome: R-HSA-5617472 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneCell JunctionNucleusMicrotubule Organizing CenterCentrosomeP-BodyShuttles Between The Cytoplasm And The NucleusLocalizes On Centrosomes During G2-M PhasePreferentially Co- Localizes With Cadherin-Adhesive Complexes At Sites Of Cell-Cell ContactsColocalizes With Gfi1 In The Nucleus |
| Alternative Antibody Names | Anti-Lim Domain-Containing Protein Ajuba antibodyAnti-AJUBA antibodyAnti-JUB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
