| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AIMP1 |
| Gene ID: | 9255 |
| Uniprot ID: | AIMP1_HUMAN |
| Immunogen Region: | 25-180 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-180 of human AIMP1 (NP_001135888.1). |
| Immunogen Sequence: | MANNDAVLKRLEQKGAEADQ IIEYLKQQVSLLKEKAILQA TLREEKKLRVENAKLKKEIE ELKQELIQAEIQNGVKQIPF PSGTPLHANSMVSENVIQST AVTTVSSGTKEQIKGGTGDE KKAKEKIEKKGEKKEKKQQS IAGSADSKPIDVSRLD |
| Post Translational Modifications | Cleaved by caspase-7 in response to apoptosis to produce EMAP-II. |
| Function | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. |
| Protein Name | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 Multisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2 Emap-2 Endothelial Monocyte-Activating Polypeptide Ii Emap-Ii Small Inducible Cytokine Subfamily E Member 1 |
| Database Links | Reactome: R-HSA-2408522 Reactome: R-HSA-379716 Reactome: R-HSA-9856649 |
| Cellular Localisation | Nucleus Cytoplasm Cytosol Secreted Endoplasmic Reticulum Golgi Apparatus Enriched In Secretory Vesicles Of Pancreatic Alpha Cells And Secreted From The Pancreas In Response To Low Glucose Levels Secreted In Response To Hypoxia Also Secreted In Response To Both Apoptotic And Necrotic Cell Death |
| Alternative Antibody Names | Anti-Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 antibody Anti-Multisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2 antibody Anti-Emap-2 antibody Anti-Endothelial Monocyte-Activating Polypeptide Ii antibody Anti-Emap-Ii antibody Anti-Small Inducible Cytokine Subfamily E Member 1 antibody Anti-AIMP1 antibody Anti-EMAP2 antibody Anti-SCYE1 antibody |
Information sourced from Uniprot.org