| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AICDA (17-130) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AICDA |
| Gene ID: |
57379 |
| Uniprot ID: |
AICDA_HUMAN |
| Immunogen Region: |
17-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 17-130 of human AICDA (NP_065712.1). |
| Immunogen Sequence: |
NVRWAKGRRETYLCYVVKRR DSATSFSLDFGYLRNKNGCH VELLFLRYISDWDLDPGRCY RVTWFTSWSPCYDCARHVAD FLRGNPNLSLRIFTARLYFC EDRKAEPEGLRRLH |
| Tissue Specificity | Strongly expressed in lymph nodes and tonsils. |
| Post Translational Modifications | Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126. |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |
| Protein Name | Single-Stranded Dna Cytosine DeaminaseActivation-Induced Cytidine DeaminaseAidCytidine Aminohydrolase |
| Cellular Localisation | NucleusCytoplasmCytosolPredominantly CytosolicIn The Presence Of Mcm3ap/GanpRelocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Single-Stranded Dna Cytosine Deaminase antibodyAnti-Activation-Induced Cytidine Deaminase antibodyAnti-Aid antibodyAnti-Cytidine Aminohydrolase antibodyAnti-AICDA antibodyAnti-AID antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
