| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AGMAT (1-352) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AGMAT |
| Gene ID: |
79814 |
| Uniprot ID: |
GDAH_HUMAN |
| Immunogen Region: |
1-352 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human AGMAT (NP_079034.3). |
| Immunogen Sequence: |
MLRLLASGCARGPGPGVGAR PAAGLFHPGRRQSRQASDAP RNQPPSPEFVARPVGVCSMM RLPVQTSPEGLDAAFIGVPL DTGTSNRPGARFGPRRIREE SVMLGTVNPSTGALPFQSLM VADLGDVNVNLYNLQDSCRR IQEAYEKIVAAGCIPLTLGG DHTITYPILQAMAKKHGPVG LLHVDAHTDTTDKALGEKLY HGAPFRRCVDEGLLDCKRVV QIGIRGSSTTLDPYRYNRS |
| Tissue Specificity | Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord. |
| Function | Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency. |
| Protein Name | Guanidino Acid Hydrolase - MitochondrialArginase - MitochondrialGuanidinobutyrase - MitochondrialGuanidinopropionase - Mitochondrial |
| Database Links | Reactome: R-HSA-351143 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Guanidino Acid Hydrolase - Mitochondrial antibodyAnti-Arginase - Mitochondrial antibodyAnti-Guanidinobutyrase - Mitochondrial antibodyAnti-Guanidinopropionase - Mitochondrial antibodyAnti-AGMAT antibodyAnti-GDAH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
