| Tissue Specificity | Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. |
| Post Translational Modifications | Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage. |
| Function | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
| Protein Name | Arf-Gap With Gtpase - Ank Repeat And Ph Domain-Containing Protein 2Agap-2Centaurin-Gamma-1Cnt-G1Gtp-Binding And Gtpase-Activating Protein 2Ggap2Phosphatidylinositol 3-Kinase EnhancerPike |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Arf-Gap With Gtpase - Ank Repeat And Ph Domain-Containing Protein 2 antibodyAnti-Agap-2 antibodyAnti-Centaurin-Gamma-1 antibodyAnti-Cnt-G1 antibodyAnti-Gtp-Binding And Gtpase-Activating Protein 2 antibodyAnti-Ggap2 antibodyAnti-Phosphatidylinositol 3-Kinase Enhancer antibodyAnti-Pike antibodyAnti-AGAP2 antibodyAnti-CENTG1 antibodyAnti-KIAA0167 antibody |
Information sourced from Uniprot.org
