Anti-ADAM9 nanobody [SAA1216] (STJN000265)

SKU:
STJN000265
£378.50 - £1,632.50
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1216
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: ADAM9
Gene ID: 8754
Uniprot ID: ADAM9_HUMAN
Post Translational Modifications Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
Function Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).
Protein Name Disintegrin And Metalloproteinase Domain-Containing Protein 9
Adam 9
Cellular Disintegrin-Related Protein
Meltrin-Gamma
Metalloprotease/Disintegrin/Cysteine-Rich Protein 9
Myeloma Cell Metalloproteinase
Database Links Reactome: R-HSA-1442490
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Nanobody Names Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 nanobody
Anti-Adam 9 nanobody
Anti-Cellular Disintegrin-Related Protein nanobody
Anti-Meltrin-Gamma nanobody
Anti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 nanobody
Anti-Myeloma Cell Metalloproteinase nanobody
Anti-ADAM9 nanobody
Anti-KIAA0021 nanobody
Anti-MCMP nanobody
Anti-MDC9 nanobody
Anti-MLTNG nanobody

Information sourced from Uniprot.org