| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAM15 |
| Gene ID: | 8751 |
| Uniprot ID: | ADA15_HUMAN |
| Immunogen Region: | 540-700 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-700 of human ADAM15 (NP_003806.3). |
| Immunogen Sequence: | QPAAPLCLQTANTRGNAFGS CGRNPSGSYVSCTPRDAICG QLQCQTGRTQPLLGSIRDLL WETIDVNGTELNCSWVHLDL GSDVAQPLLTLPGTACGPGL VCIDHRCQRVDLLGAQECRS KCHGHGVCDSNRHCYCEEGW APPDCTTQLKATSSLTTGLL L |
| Tissue Specificity | Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs. |
| Function | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 15 Adam 15 Metalloprotease Rgd Disintegrin Protein Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 Mdc-15 Metargidin |
| Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-8941237 |
| Cellular Localisation | Endomembrane System Single-Pass Type I Membrane Protein Cell Junction Adherens Junction Cell Projection Cilium Flagellum Cytoplasmic Vesicle Secretory Vesicle Acrosome The Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late Endosome The Pro-Protein Is The Major Detectable Form On The Cell Surface Whereas The Majority Of The Protein In The Cell Is Processed |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 15 antibody Anti-Adam 15 antibody Anti-Metalloprotease Rgd Disintegrin Protein antibody Anti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 antibody Anti-Mdc-15 antibody Anti-Metargidin antibody Anti-ADAM15 antibody Anti-MDC15 antibody |
Information sourced from Uniprot.org