• Western blot analysis of the lysates from RAW264.7cells using CXCR7 antibody.
  • Immunofluorescence analysis of COS7 cells, using CXCR7 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from COS7 cells, using CXCR7 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using CXCR-7 Polyclonal Antibody diluted at 1:2000

Anti-ACKR3 antibody (311-360 aa) (STJ92527)


Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse/Rat/Monkey
Short Description: Rabbit polyclonal antibody anti-Atypical chemokine receptor 3 (311-360 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACKR3
Gene ID: 57007
Immunogen Region: 311-360 aa
Specificity: CXCR-7 Polyclonal Antibody detects endogenous levels of CXCR-7 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CXCR7 at the amino acid range 311-360
Post Translational Modifications The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels. (Microbial infection) Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Protein Name Atypical Chemokine Receptor 3
C-X-C Chemokine Receptor Type 7
Chemokine Orphan Receptor 1
G-Protein Coupled Receptor 159
G-Protein Coupled Receptor Rdc1 Homolog
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Early Endosome
Recycling Endosome
Predominantly Localizes To Endocytic Vesicles
And Upon Stimulation By The Ligand Is Internalized Via Clathrin-Coated Pits In A Beta-Arrestin-Dependent Manner
Once Internalized
The Ligand Dissociates From The Receptor
And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Antibody Names Anti-Atypical Chemokine Receptor 3 antibody
Anti-C-X-C Chemokine Receptor Type 7 antibody
Anti-Cxc-R7 antibody
Anti-Cxcr-7 antibody
Anti-Chemokine Orphan Receptor 1 antibody
Anti-G-Protein Coupled Receptor 159 antibody
Anti-G-Protein Coupled Receptor Rdc1 Homolog antibody
Anti-Rdc-1 antibody
Anti-ACKR3 antibody
Anti-CMKOR1 antibody
Anti-CXCR7 antibody
Anti-GPR159 antibody
Anti-RDC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance