• Immunofluorescence analysis of A549 cells, using CCBP2 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-ACKR2 antibody (310-390 C-Term) (STJ92260)


Current Stock:
Host: Rabbit
Applications: IF, ICC, ELISA
Reactivity: Human, Rat, Mouse
Short Description: Rabbit polyclonal antibody anti-Atypical Chemokine Receptor 2 (310-390 C-Term) is suitable for use in Immunofluorescence, Immunocytochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACKR2
Gene ID: 1238
Immunogen Region: 310-390 C-Term
Specificity: ACKR2 polyclonal antibody (Atypical Chemokine Receptor 2) binds to endogenous Atypical Chemokine Receptor 2 at the amino acid region 310-390 C-Term.
Immunogen: The antiserum was produced against synthesized peptide derived from human CCBP2 at amino acid range 335-384
Post Translational Modifications Phosphorylated on serine residues in the C-terminal cytoplasmic tail.
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Protein Name Atypical Chemokine Receptor 2
C-C Chemokine Receptor D6
Chemokine Receptor Ccr-10
Chemokine Receptor Ccr-9
Chemokine-Binding Protein 2
Chemokine-Binding Protein D6
Database Links Reactome: R-HSA-380108
Cellular Localisation Early Endosome
Recycling Endosome
Cell Membrane
Multi-Pass Membrane Protein
Predominantly Localizes To Endocytic Vesicles
And Upon Stimulation By The Ligand Is Internalized Via Clathrin-Coated Pits
Once Internalized
The Ligand Dissociates From The Receptor
And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Antibody Names Anti-Atypical Chemokine Receptor 2 antibody
Anti-C-C Chemokine Receptor D6 antibody
Anti-Chemokine Receptor Ccr-10 antibody
Anti-Chemokine Receptor Ccr-9 antibody
Anti-Chemokine-Binding Protein 2 antibody
Anti-Chemokine-Binding Protein D6 antibody
Anti-ACKR2 antibody
Anti-CCBP2 antibody
Anti-CCR10 antibody
Anti-CMKBR9 antibody
Anti-D6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance