• Western blot with Anti-ACKR2 Antibody (FITC) (STJ500033) with peptide on at 1:500 dilution in buffer.

Anti-ACKR2 antibody (200-300) {FITC} (STJ500033)


Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Short Description: Rabbit polyclonal antibody anti-ACKR2 (200-300) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ACKR2
Gene ID: 1238
Immunogen Region: 200-300
Immunogen: Synthetic peptide taken within amino acid region 200-300 on ACRD6 protein.
Tissue Specificity Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.
Post Translational Modifications Phosphorylated on serine residues in the C-terminal cytoplasmic tail.
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Protein Name Atypical Chemokine Receptor 2
C-C Chemokine Receptor D6
Chemokine Receptor Ccr-10
Chemokine Receptor Ccr-9
Chemokine-Binding Protein 2
Chemokine-Binding Protein D6
Database Links Reactome: R-HSA-380108
Cellular Localisation Early Endosome
Recycling Endosome
Cell Membrane
Multi-Pass Membrane Protein
Predominantly Localizes To Endocytic Vesicles
And Upon Stimulation By The Ligand Is Internalized Via Clathrin-Coated Pits
Once Internalized
The Ligand Dissociates From The Receptor
And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Antibody Names Anti-Atypical Chemokine Receptor 2 antibody
Anti-C-C Chemokine Receptor D6 antibody
Anti-Chemokine Receptor Ccr-10 antibody
Anti-Chemokine Receptor Ccr-9 antibody
Anti-Chemokine-Binding Protein 2 antibody
Anti-Chemokine-Binding Protein D6 antibody
Anti-ACKR2 antibody
Anti-CCBP2 antibody
Anti-CCR10 antibody
Anti-CMKBR9 antibody
Anti-D6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance