||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Acetyl-Eukaryotic Translation Initiation Factor 5a-2-K47 (11-60) is suitable for use in Western Blot and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000ELISA 1:20000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||Acetyl-EIF5A2-K47 polyclonal antibody (Eukaryotic Translation Initiation Factor 5a-2) binds to endogenous Eukaryotic Translation Initiation Factor 5a-2 at the amino acid region 11-60.
||The antiserum was produced against synthesized Acetyl-peptide derived from human eIF5A around the Acetylation site of Lys47 at amino acid range 11-60
| Post Translational Modifications || eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine). |
| Function || mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. |
| Protein Name || Eukaryotic Translation Initiation Factor 5a-2Eif-5a-2Eif-5a2Eukaryotic Initiation Factor 5a Isoform 2 |
| Database Links || Reactome: R-HSA-204626 |
| Cellular Localisation || CytoplasmNucleusEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideNuclear Pore ComplexHypusine Modification Promotes The Nuclear Export And Cytoplasmic Localization And There Was A Dynamic Shift In The Localization From Predominantly Cytoplasmic To Primarily Nuclear Under Apoptotic Inducing Conditions |
| Alternative Antibody Names || Anti-Eukaryotic Translation Initiation Factor 5a-2 antibodyAnti-Eif-5a-2 antibodyAnti-Eif-5a2 antibodyAnti-Eukaryotic Initiation Factor 5a Isoform 2 antibodyAnti-EIF5A2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance