| Post Translational Modifications | Glycosylated. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains. Ubiquitinated. Ubiquitinated on Lys-788 via 'Lys-48'-linked ubiquitin. 'Lys-48'-linked deubiquitinated by USP50 on the Lys-788.leading to its stabilization. |
| Function | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity. |
| Protein Name | Angiotensin-Converting Enzyme 2Ace-Related Carboxypeptidase Cleaved Into - Processed Angiotensin-Converting Enzyme 2 |
| Database Links | Reactome: R-RNO-2022377 |
| Cellular Localisation | Processed Angiotensin-Converting Enzyme 2: SecretedCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmCell ProjectionCiliumApical Cell MembraneDetected In Both Cell Membrane And Cytoplasm In Neurons |
| Alternative Antibody Names | Anti-Angiotensin-Converting Enzyme 2 antibodyAnti-Ace-Related Carboxypeptidase Cleaved Into - Processed Angiotensin-Converting Enzyme 2 antibodyAnti-Ace2 antibody |
Information sourced from Uniprot.org
