Anti-ABL2 antibody (1100-1150) {FITC} (STJ506090)


Current Stock:
Host: Rabbit
Applications: ELISA, IP, WB
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal antibody anti-ABL2 (1100-1150) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ABL2
Gene ID: 27
Uniprot ID: ABL2_HUMAN
Immunogen Region: 1100-1150
Immunogen: Synthetic peptide corresponding to amino acids within region 1100-1150 on human Tyrosine-protein kinase ABL2/ARG.
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB. Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
Function Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement).CTTN (involved in signaling).or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
Protein Name Tyrosine-Protein Kinase Abl2
Abelson Murine Leukemia Viral Oncogene Homolog 2
Abelson Tyrosine-Protein Kinase 2
Abelson-Related Gene Protein
Tyrosine-Protein Kinase Arg
Database Links Reactome: R-HSA-428890
Reactome: R-HSA-9013149
Reactome: R-HSA-9013423
Reactome: R-HSA-9706369
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Abl2 antibody
Anti-Abelson Murine Leukemia Viral Oncogene Homolog 2 antibody
Anti-Abelson Tyrosine-Protein Kinase 2 antibody
Anti-Abelson-Related Gene Protein antibody
Anti-Tyrosine-Protein Kinase Arg antibody
Anti-ABL2 antibody
Anti-ABLL antibody
Anti-ARG antibody

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